The Goldfields-Esperance region is located in the south-eastern corner of Western Australia and incorporates nine local government areas: the City of Kalgoorlie-Boulder and the Shires of Coolgardie, Dundas, Esperance, Laverton, Leonora, Menzies, Ngaanyatjarraku, and Ravensthorpe.

A land area of 771,276 km² makes the region over three times the size of the state of Victoria, and just under a third of Western Australia's total land mass. It is the largest region in Western Australia. It is bounded geographically by the Little Sandy Desert and Gibson Desert to the North; the Wheatbelt region to the West; the Great Australia Bight to the South; and the South Australian and Northern Territory borders to the East.

The Goldfields-Esperance region has a population of just under 60,000 people and is comprised of three sub-regions: the Goldfields sub-region, the Esperance sub-region and the Northern Goldfields sub-region, which includes the 'Lands'.

The Goldfields sub-region has a highly dispersed population. It is a mining and pastoral region that includes Kalgoorlie-Boulder and the towns of Norseman, Coolgardie, Kambalda, Menzies, Leonora, Laverton and Leinster. Mining is the largest driver of the Goldfields' economy. The mining industry has resulted in the northern part of the sub-region’s workforce being highly transient, with many mining enterprises operating on a fly-in-fly-out basis.

The Esperance sub-region is the area south of Norseman that includes the towns of Esperance, Munglinup, Condingup, Ravensthorpe, Hopetoun, Grass Patch, Salmon Gums, Gibson and Scaddan. It has significant coastal assets and a mixed economy of agriculture, fisheries and mining. Esperance Port provides infrastructure for the whole region as the entry and exit point for north to south transport. Tourism based on natural attractions, is an important and growing industry in the region. The population is more evenly distributed in age than that of the Goldfields and is not characterised by a highly transient workforce.

Ngaanyatjarra Lands (The Lands) are largely unallocated Crown Land within the Shire of Ngaanyatjarraku, populated with widely dispersed remote Aboriginal communities. Many of these remote communities lie close to the West Australian/Northern Territory and South Australian borders, with the sub-regional centre of Warburton approximately 750 kilometres from the Goldfields centre of Kalgoorlie-Boulder. In addition to private general practice opportunities, Kalgoorlie and Esperance offer some great opportunities for procedural practice in a well-supported environment. In Kalgoorlie, there are good obstetric opportunities, with 800 births per year and two resident obstetricians for back up, abundant paediatrics (the town is full of children), and the opportunity to admit to the local hospital. There are particularly good opportunities for work in Aboriginal health in Kalgoorlie - Bega Garnbirringu is a state of the art AMS, well-equipped with 5-6 doctors, who work in a team with Aboriginal health workers.