GP Registrar Academic Post

Curtin Medical School offers a GP registrar to be involved in teaching at Curtin as Problem Based Learning (PBL) & Clinical Skill (CS) tutors for the year 1, 2 & 3 medical students.

The GP registrar will be involved in research in the planning-to-establish Joint Hypertension Diagnosis & Cardiovascular Risk Assessment clinic at both the Curtin Medical School and the School of Public Health, Faculty of Health Sciences, Curtin University

Research project 1: The possible role of sodium-glucose cotransporter-2 inhibitors in primary prevention of cardiovascular diseases in low risk or healthy individual.

Project overview: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been studied in several large cardiovascular outcomes trials in patients with type 2 diabetes. These trials were done to satisfy regulatory requirements, specifically to exclude an excess in risk of cardiovascular death, myocardial infarction, or stroke (ie, major adverse cardiovascular events) and to test for efficacy. SGLT2is appears to moderately reduce the risk of major adverse cardiovascular events (MACE), or at least some components of them. However, the apparent greater benefit of SGLT2i on MACE in patients with established atherosclerotic cardiovascular disease than in those with multiple risk factors but without atherosclerotic cardiovascular disease complicates the interpretation of these research evidence. This has also been suggested in other studies and meta-analyses and remains an active area of research. 

The team aims to:

  1. Compose a protocol paper for a systematic literature review on SGLT2i&CE during the period January 2020-January 2021,
  2. Complete a systematic literature review during the period of 2020-2021 and
  3. Develop a proposal on SGLT2i&CE for NHMRC for submission by May 2021. 

Specifically, the GP registrar will:

  1. Search database, create and maintain an Endnote library over the summer period,
  2. Screen relevant articles and assess quality of shortlisted articles using the Joanna Brigg’s Institute (JBI) guideline,
  3. Prepare a flowchart according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and tables containing key information of the shortlisted articles, and
  4. Draft the systematic literature review on MSGLT2i&CE by January 2020.

The expected outcomes for the GP registrar include:

  1. Gain expertise in using scholarly databases, searching and exporting references to Endnote library and maintaining the library,
  2. Apply the PRISMA guideline and critically assess quality of peer-reviewed articles using the JBI guideline, and
  3. Improve academic writing skill in the form of a systematic literature review and journal manuscript.

 

Research project 2: The research project will be to perform an audit on the prevalence of resistant hypertension in Western Australian general practice clinics

Project overview: True resistant hypertension is defined as blood pressure that remains above goal despite concurrent use of three antihypertensive agents from different classes, one of which should be a diuretic. Patients whose blood pressure is controlled with four or more medications are considered to have resistant hypertension as well. This project is to audit fifty GP clinics in Western Australian to establish the prevalence of resistant hypertension with an aim to facilitate potential new pharmacological interventional drug trial in a current study and future study. Dr Daniel Xu & Prof Christopher Reid are currently the investigators for the Precision (Aprocitentan being the Endothelial Receptor Antagonist as the investigational drug)—a study for patients with resistant hypertension. 

The team aims to:

  1. Audit on the prevalence of resistant hypertension in Western Australian general practice clinics during the period January 2020-January 2021;
  2. Complete the audit and compose a publication during the period of 2020-2021 and 3) Establish the Hypertension Diagnosis & Cardiovascular Risk Assessment clinic at Curtin University to facilitate future clinical drug trial and research for hypertension and other cardiovascular diseases. 

Specifically, the GP registrar will: 

  1. Search GP practice database, create and maintain the true resistant hypertensive patients’ record,
  2. Resistant hypertension literature review & screen for new GP clinics to be involved in the audit process,
  3. Draft the paper on the prevalence of resistant hypertension in WA GP clinics by January 2021.

The expected outcomes for the GP registrar include:

  1. Gain expertise in using GP practice software to perform auditing
  2. Improve academic writing skill in the form of an observational study and journal manuscript.

Tangible outputs and reporting:

  1. An observational study to be submitted to quality journal (e.g. Journal of Hypertension, International Journal of Hypertension, Cardiology in Review) for publication in June 2021,
  2. An updated evidence-based literature review for use in the NHMRC grant proposal to be submitted in May 2021,
  3. Improved track record and research capacity of the team,
  4. Success in future pilot grants, and
  5. Master and PhD projects from the Hypertension Diagnosis & Cardiovascular Risk Assessment clinic.

For more information on these research projects or to express interest, contact Dr Daniel Xu at Curtin University:

Location | Building 410, Level 5, Room 526
Postal Address | GPO Box U1987, Perth, Western Australia, 6845 | AUSTRALIA
Tel | +61 (0)8 9266 1740
Mobile | +61 (0)415288896
Email | daniel.xu@curtin.edu.au